Table 3.

Enrichment of Variants With Improved Binding Affinity (ΔΔG < −1.0 kcal/mol for All‐Variant Analysis or ΔΔG < −0.5 kcal/mol for SPM) Using Rank‐by‐Number, Rank‐by‐Rank, and Rank‐by‐Best Consensus Schemes Computed Using FoldX and Discovery Studio Predictions Only

	All					SPM
% Database	FoldX	Discovery Studio	Rank‐by‐number	Rank‐by‐rank	Rank‐by‐best	FoldX	Discovery Studio	Rank‐by‐number	Rank‐by‐rank	Rank‐by‐best
1	12.7	11.4	14.3	14.3	9.5	0.0	0.0	0.0	0.0	0.0
5	8.9	6.5	9.8	9.8	6.4	2.2	2.2	1.5	0.7	3.6
10	6.0	5.1	6.4	6.4	4.7	1.8	2.9	2.2	2.6	4.4
15	4.3	4.2	4.4	4.4	3.7	2.0	2.2	2.9	2.5	3.4
20	3.4	3.4	3.5	3.5	3.3	2.0	2.0	3.1	2.4	3.5
30	2.4	2.5	2.8	2.6	2.6	1.8	1.8	2.3	2.1	2.7
40	2.1	2.1	2.1	2.2	2.2	1.7	1.8	2.1	1.9	2.3
50	1.7	1.8	1.9	1.9	1.9	1.6	1.7	1.8	1.8	1.8