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. 2016 Apr;68(2):357–418. doi: 10.1124/pr.115.011833

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Copyright © 2016 The Author(s)

This is an open access article distributed under the CC-BY Attribution 4.0 International license.

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Fig. 12. — Three-dimensional alignments shown as a top view (A) and the side view (B) of the 11-molecule cluster of ET antagonists using ChemAxon Marvin tool at default settings to perform a flexible overlap of atoms via on-the-fly adjustments. The following 11 were selected as having high affinity: peptide antagonist FR139317 and nonpeptide antagonists, A127722, ambrisentan, avosentan, darusentan, macitentan, PD156707, PD164333, SB234551, sitaxentan, and zibotentan. Top (C) and side view (D) of a three-molecule cluster of ET_B peptide antagonist, BQ788, and nonpeptide antagonists A192621 and RO468443.