TABLE 3.

Summary of phenotype of rats with genetic alterations of the endothelin system

Animal Model	Site (Cre)	Phenotype	References
TGR(hET-2)37	Whole body ET-2 overexpression	males: lower body weight, interstitial and glomerularsclerosis	Liefeldt et al., 1995, 1999
		females: glomerularsclerosis	Liefeldt et al., 1999
Homozygous spotting lethal (sl/sl)	Whole body, natural mutation in the ETB	aganglionic megacolon; white coat color; death at an early age.	Gariepy et al., 1996
DβH-ETB:ETBsl/sl	ETB deficient except for nerves (insertion with dopamine-β-hydroxylase promoter)	ETB expressed in nerves but absent elsewhere; coat color spotting; salt-sensitive hypertension	Gariepy et al., 1998; Gariepy et al., 2000; Pollock et al., 2000