Figure 1.

(A) Schematic representation of the multi‐component Sin3A corepressor complex. The complex comprises at least ten proteins (see text for details). Sin3‐associated protein 30 (SAP30) mediates the key DNA and phospholipid interactions of the complex and also associates with histone 2A/2B proteins as well as other transcription factors (e.g., NCoR and YY1; see text for details). (B) Known functional motifs in SAP30L. ZnF, a zinc finger motif; NLS, nuclear localization signal; NoLS, nucleolar localization signal; PIP, phosphatidylinositol phosphate. (C) The zinc finger motif of SAP30L. The expressed construct comprises residues 25–92 of the full‐length SAP30L. The construct also contains two additional N‐terminal residues (GS) from the expression vector (thrombin cleavage site).