Table 2.
We identified the target peptides among the H7, N7 and N2 subtypes of concern. The N* and H* means from any NA or HA strain. The peptides that are shown in gray were not analyzed in this method. All full-length HA and NA sequences for the H7N7 and H7N2 strains were analyzed through July 24, 2013. Peptides that are conserved among the strains are most valuable as the need to generate new peptide standards upon annual strain changes is less likely.
| Target Peptide Sequence | # strains of this subtype in NCBI database as of July 24, 2013 | # of strains containing target peptide | Extent of conservation of target peptide | |
|---|---|---|---|---|
| H7N* | VNTLTER | 1463 | 1116 | 76% |
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| FVNEEALR | 434 | 84% (combined) | ||
| FTNEESLR | 800 | |||
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| IQIDPVK | 1120 | 77% | ||
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| STQSAIDQITGK | 1178 | 81% | ||
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| H*N7 | IPNAGTDPNSR | 688 | 400 | 83% (combined) |
| IPNAETDPNSK | 172 | |||
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| FGESEQIIVTR | 542 | 79% | ||
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| H9N2, H7N2 | SGYETFR | 1693 | 1249 | 74% |
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| H*N9 | IGESSDVLVTR | 538 | 67 | 89% (combined) |
| IGENSDVLVTR | 163 | |||
| IGEDSDVLVTR | 247 | |||
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| FYALSQGTTIR | 502 | 93% | ||
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| VPNALTDDR | 499 | 93% | ||