Table 3.
Differences in Resting State Functional Connectivity between Controls and Adults with Attention-Deficit Hyperactivity Disorder (ADHD) at Baseline
Network and Regions | MNI Coordinate | Cluster Size (voxels)a | Cluster-Level FWE- Corrected P b | T Value | Functional Connectivity (Rz), Mean (SD) | |
---|---|---|---|---|---|---|
Control | ADHD | |||||
Control>ADHD | ||||||
Dorsal attention network | ||||||
Left FEF, right fusiform gyrus/inferior temporal gyrus (BA 20/37) | 42, -42, -12 | 289 | .014 | T=5.1 | 0.23 (0.18) | -0.02 (0.14) |
Right FEF, right parahippocampal/fusiform gyrus | 33, -39, -18 | 252 | .032 | T=4.18 | 0.21 (0.15) | -0.01 (0.21) |
Right FEF, right middle frontal gyrus (BA 8) | 18, 24, 45 | 293 | .015 | T=4.71 | 0.17 (0.18) | -0.07 (0.21) |
Cognitive control network | ||||||
Left DLPFC, precuneus/posterior cingulate gyrus (BA 31/30)c | -21, -36, -3 | 953 | <.001 | T=5.23 | -0.29 (0.24) | -0.02 (0.20) |
Right DLPFC, mPFC (BA 32/10)c,d | 9, 48, -6 | 214 | .053d | T=4.74 | -0.15 (0.16) | 0.05 (0.16) |
DMN | ||||||
Left PRE, right middle temporal/fusiform gyrus (BA 20/21) | 33, -9, -33 | 278 | .02 | T=4.59 | 0.29 (0.22) | -0.01 (0.17) |
ADHD and Control with reversed patterns in terms of positive and negative connections | ||||||
Dorsal attention network | ||||||
Right FEF, left middle temporal/angular gyrus (BA 39)c | -39, -69, 15 | 277 | .02 | T=5.34 | 0.09 (0.17) | -0.15 (0.16) |
Right FEF, left middle frontal gyrus (BA 8)c | -30, 24, 39 | 234 | .045 | T=4.71 | 0.08 (0.14) | -0.12 (0.18) |
Abbreviations: BA, Brodmann area; DLPFC, dorsolateral prefrontal cortex; DMN, default mode network; FEF, frontal eye field; FWE, Family-wise error; MNI, Montreal Neurological Institute; mPFC, medial prefrontal cortex; PRE, precuneus; Rz, z-transformed Pearson’s correlational coefficient.
aThe normalized voxel was resampled to the size of isotropic 3mm.
bThe cluster-forming threshold was set at voxel-level P<.01.
cDifferences were displayed in negative functional connectivity between the 2 groups.
dTrend-level significance.