Table 5.
Significant Differences in Functional Connectivity From Multiple Regression with Changes in Clinical Symptoms and Neuropsychological Performances
| Network and Regions | MNI Coordinate | Cluster Size (voxels)a | Cluster-Level FWE-Corrected P b | T-value | Behavioral measures | Direction of Correlation |
|---|---|---|---|---|---|---|
| Ventral attention network | ||||||
| Left TPJ, left middle temporal/ temporal pole (BA 21/38) | -42, 27, -18 | 589 | <0.001 | T=7.98 | Inattention | Positive |
| Left TPJ, left middle frontal gyrus/VFC (BA 46) | -51, 30, 21 | 647 | <0.001 | T=9.46 | RVP hits | Positive |
| Left VFC, left posterior TPJ (BA 39) | -48, -48, 24 | 393 | 0.001 | T=5.53 | Inattention | Positive |
| Left VFC, left posterior TPJ (BA 39) | -45, -48, 21 | 250 | 0.014 | T=6.29 | Hyperactivity/ impulsivity | Positive |
| Right VFC, left middle temporal gyrus (BA 21) | -57, -30, -15 | 193 | 0.046 | T=7.91 | Inattention | Positive |
| Right VFC, left posterior TPJ (BA 39) | -36, -54, 21 | 237 | 0.017 | T=5.73 | Inattention | Positive |
| Dorsal attention network | ||||||
| Right IPS, precuneus/cuneus (BA 18/7) | 0, -84, 12 | 236 | 0.022 | T=5.06 | Inattention | Negative |
| Right IPS, precuneus/cuneus (BA 7/31) | 12, -72, 24 | 234 | 0.026 | T=4.32 | Hyperactivity/ impulsivity | Negative |
| Cognitive control network | ||||||
| Left DLPFC, right TPJ (BA 40) | 69, -27,15 | 235 | 0.019 | T=7.40 | RVP hits | Positive |
| Left DLPFC, right precentral gyrus (BA 6) | 30, -15, 66 | 335 | 0.002 | T=6.82 | RVP hits | Positive |
| Right DLPFC, left mid-cingulate | -12, 6, 39 | 383 | 0.001 | T=10.30 | RVP hits | Positive |
| DMN | ||||||
| PCC, left middle/inferior occipital (BA 18) | -30, -84, -3 | 294 | 0.007 | T=5.67 | Hyperactivity/ impulsivity | Positive |
| PCC, middle occipital/calcarine (BA 18) | -9, -102, 3 | 330 | 0.003 | T=5.94 | RVP hits | Negative |
aThe normalized voxel was resampled to the size of isotropic 3mm.
bThe cluster-forming threshold was set at voxel-level P<.01.
Abbreviations: ACC, anterior cingulate cortex; BA, Brodmann area; DLPFC, dorsolateral prefrontal cortex; DMN, default mode network; FEF, frontal eye field; FWE, Family-wise error; IPS, inferior parietal sulcus; MNI, Montreal Neurological Institute; mPFC, medial prefrontal cortex; PCC, posterior cingulate cortex; PRE, precuneus; RVP, Rapid Visual Information Processing; TPJ, temporoparietal junction; VFC, ventral frontal cortex.