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. 2016 Mar 31;10:135. doi: 10.3389/fnins.2016.00135

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Copyright © 2016 Killian, Vernekar, Potter and Vukasinovic.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Perfusion increased spontaneous firing rates of both slices and 3-D cell cultures. The mean spike detection rate (Hz) per electrode was higher in perfused (+P) cultures compared to unperfused (−P) control cultures (^*P < 0.05, two-sample t-test). A single average firing rate value was taken at each DIV for each culture type. The effect of perfusion was statistically significant as analyzed with 2-way ANOVA (P < 0.05; nine slices, six 3-D cultures, see Results for more details). This relatively greater firing rate for perfused cultures may reflect either more live cells near electrodes or greater cellular activity.