Table 1. A review of genes identified in linkage or association with PACG and/or PACG predisposing traits.

Gene	Phenotype	Location	Authors
NNO1	Nanophthalmos, hyperopia and ACG	11p13	Othman et al61
PLEKHA7, COL11A1, PCMTD1 and ST18	PACG	11p15, 1p21, 8q11.23	Vithana et al62
COL1A1	Myopia	1p21	Inamori et al,64 Zhang et al65
MMP9	PACG	20q13.12	Awadalla et al,73 Cong et al,69 Wang et al,70 Micheal et al71
MTHFR	PACG, anterior segment extracellular matrix (ECM) remodeling	1p36.3	Micheal et al76
MFRP	PACG	11q23.3	Wang et al,77 Aung et al,72 Shi et al103
MFRP	Autosomal recessive nanophthalmos, short axial length, high degree of hyperopia, high lens-to-eye-volume ratio and small corneal diameter	11q23.3	Sundin et al79
CHX10	PACG	14q24.3	Aung et al72
HGF	PACG and hyperopia	7q21.1	Awadalla et al,86 Jiang et al85
RSPO1, C3orf26, LAMA2, GJD2, ZNRF3, CD55, MIP, ALPPL2 and ZC3H11B	Axial length regulation	1p34.3, 3q12.1, 6q22.33, 15q14, 22q12.1, 1q32, 12q13, 2q37, 1q41	Cheng et al87
PRSS56	ACG, posterior microphthalmia	2q37.1	Nair et al93
ABCC5	PACG, ACD regulation	3q27	Nongpiur et al94
MYOC	ACG	1q24.3	Faucher et al,98 Dai et al100
CYP1B1	PACG	2p22.2	Chakrabarti et al,101 Dai et al100
eNOS	PACG, ACD regulation	7q36	Ayub et al,102
HSP70	PACG	19q13.42	Ayub et al,102 Shi et al103
SPARC	PACG, IOP regulation	5q33.1	Yan et al,109 Chua et al,104 Haddadin et al110
CALCRL	Acute PACG	2q32.1	Cao et al111
NEB	Canine PACG		Ahram et al118