Table 3. Results of meta-analysis between normal tension glaucoma, high tension glaucoma and healthy subjects.
| Group | Parameters | Ren et al15 | Siaudvytyte et al24 | Berdahl et al26 | Total |
|---|---|---|---|---|---|
| NTG group | Number of patients (N (%)) | 14 (41.2%) | 9 (26.5%) | 11 (32.3%) | 34 (100%) |
| Age (years) | 49.6 (12.1) | 56.6 (10.4) | 68.0 (17.1) | 57.4 (8.0)* | |
| IOP (mm Hg) | 16.1 (1.9) | 13.7 (1.6) | 17.3 (2.7) | 15.9 (1.4)** | |
| ICP (mm Hg) | 9.5 (2.2) | 7.4 (2.7) | 9.3 (3.2) | 8.7 (0.9)*** | |
| TPD (mm Hg) | 6.6 (3.6) | 6.3 (3.1) | 7.4 (4.8) | 6.8 (0.5)**** | |
| HTG group | Number of patients (N (%)) | 29 (76.3%) | 9 (23.7%) | — | 38 (100%) |
| Age (years) | 40.4 (16.1) | 54.7 (15.6) | — | 43.8 (6.2)* | |
| IOP (mm Hg) | 24.3 (3.2) | 24.7 (6.8) | — | 24.4 (0.2)** | |
| ICP (mm Hg) | 11.7 (2.7) | 8.9 (1.9) | — | 11.0 (1.2)*** | |
| TPD (mm Hg) | 12.5 (4.1) | 15.7 (7.7) | — | 13.3 (1.4)**** | |
| Control group | Number of patients (N (%)) | 71 (42.8%) | 9 (5.4%) | 86 (51.8%) | 166 (100%) |
| Age (years) | 45.7 (11.3) | 51.9 (6.6) | 68.2 (8.6) | 57.7 (11.0)* | |
| IOP (mm Hg) | 14.3 (2.6) | 15.9 (2.1) | 16.1 (2.7) | 15.3 (0.9)** | |
| ICP (mm Hg) | 12.9 (1.9) | 10.5 (3.0) | 12.7 (3.9) | 12.2 (0.7)*** | |
| TPD (mm Hg) | 1.4 (1.7) | 5.4 (3.3) | 3.3 (4.0) | 2.6 (1.1)**** |
Abbreviations: HTG, high-tension glaucoma; ICP, intracranial pressure; IOP, intraocular pressure; NTG, normal tension glaucoma; TPD, translaminar pressure difference.
*P, **P, ***P and ****P are <0.05, significant difference between three groups (t-test).