Table 2B. Statistical analyses (ANOVA and nonparametric P-values) of differences in immunohistochemically detected 4E and p4E expressiona.

P-values	4E cytoplasmic HS	4E nuclear HS	p4E cytoplasmic HS	p4E nuclear HS
Dermal/compound/junctional nevi
ANOVA	0.0324	0.9337	0.0012	0.9907
Nonparametric	0.0775	0.7618	0.0094	0.5241
Nevi vs melanomas
ANOVA	<0.0001	<0.0001	<0.0001	<0.0001
Nonparametric	<0.0001	<0.0001	<0.0001	<0.0001
Clark level I, II vs ⩾III
ANOVA	0.2418	0.9298	0.2063	0.0010
Nonparametric	0.1588	0.3503	0.1676	0.0006

Abbreviations: ANOVA=analysis of variance; 4E=cytoplasmic and nuclear eukaryotic translation initiation factor 4E; eIF4E=eukaryotic translation initiation factor 4E; HS=histoscores; p4E=phosphorylated eukaryotic translation initiation factor 4E.

^aIn benign nevi and malignant melanoma histopathologic subtypes and metastatic melanoma expressed as HS=area stained × intensity of stain.