Table 2C. Correlation coefficients between patient age, melanocytic lesion histopathologic subtype, Clark level, and immunohistochemically detected 4E and p4E expressiona.

	Age	Lesion subtype	Clark level
Age
Correlation coefficient	—	0.305	0.838
P-value	—	0.0002	0.500
N	—	149	67
Tissue
Correlation coefficient	0.305	—	−0.046
P-value	0.0002	—	0.715
N	149	—	67
Clark level
Correlation coefficient	0.838	−0.046	—
P-value	0.500	0.715	—
N	67	67	—
eIF4E cytoplasmic histoscore
Correlation coefficient	0.251	0.442	0.126
P-value	0.002	<0.0001	0.309
N	146	147	67
eIF4E nuclear histoscore
Correlation coefficient	0.187	0.319	0.009
P-value	0.024	<0.0001	0.939
N	146	147	67
p4E cytoplasmic histoscore
Correlation coefficient	0.329	0.427	0.147
P-value	<0.0001	<0.0001	0.252
N	143	144	63
p4E nuclear histoscore
Correlation coefficient	0.256	0.351	0.397
P-value	0.002	<0.0001	0.001
N	143	144	63

Abbreviations: 4E=cytoplasmic and nuclear eukaryotic translation initiation factor 4E; eIF4E=eukaryotic translation initiation factor 4E; HS=histoscores; p4E=phosphorylated eukaryotic translation initiation factor 4E. For purposes of analysis each histopathologic subtype (see Table 1) was given a numerical code.

^aHS=area stained × intensity of stain.