Table 1. MHC I expression in BTC stratified by clinicopathological parameters.
| Number (%) | MHC I | MHC I | P-value | |
|---|---|---|---|---|
| IRS 0–6 (number (%)) | IRS 8–12 (number (%)) | χ2 test | ||
| All cases | 334 (100) | 175 (52.4) | 159 (47.6) | |
|
Age | ||||
| 64–92 years | 169 (50.6) | 90 (53.3) | 79 (46.7) | 0.835 |
| 31–64 years | 165 (49.4) | 85 (51.5) | 80 (48.5) | |
|
Sex | ||||
| Male | 163 (48.8) | 78 (47.9%) | 85 (52.1) | 0.13 |
| Female | 171 (51.2) | 97 (56.7%) | 74 (43.3) | |
|
BTC subgroups | ||||
| ICC | 146 (43.7) | 85 (58.2) | 61 (41.8) | 0.118 |
| ECC | 129 (38.6) | 59 (45.7) | 70 (54.3) | |
| GBAC | 59 (17.7) | 31 (52.5) | 28 (47.5) | |
|
Histology subgroups | ||||
| Ductal | 274 (82) | 146 (53.3) | 128 (46.7) | 0.187 |
| Papillary | 22 (6.6) | 8 (36.4) | 14 (63.6) | |
| Mucinous | 8 (2.4) | 3 (37.5) | 5 (62.5) | |
| Intestinal | 10 (3) | 4 (40) | 6 (60) | |
| Other | 20 (6) | 14 (70) | 6 (30) | |
|
UICC stage | ||||
| 1 | 38 (14.2) | 15 (39.5) | 23 (60.5) | 0.074 |
| 2 | 67 (25.1) | 32 (47.8) | 35 (52.2) | |
| 3 | 71 (26.6) | 33 (46.5) | 38 (53.5) | |
| 4 | 91 (34.1) | 56 (61.5) | 35 (38.5) | |
|
pT | ||||
| T1 | 73 (21.9) | 40 (54.8) | 33 (45.2) | 0.474 |
| T2 | 131 (39.2) | 62 (47.3) | 69 (52.7) | |
| T3 | 103 (30.8) | 59 (57.3) | 44 (42.7) | |
| T4 | 27 (8.1) | 14 (51.9) | 13 (48.1) | |
|
pN | ||||
| N0 | 118 (45.6) | 53 (44.9) | 65 (55.1) | 0.153 |
| N1 | 141 (54.4) | 77 (54.6) | 64 (45.4) | |
|
M | ||||
| M0 | 315 (94.3) | 161 (51.1) | 154 (48.9) | 0.094 |
| M1 | 19 (5.7) | 14 (73.7) | 5 (26.3) | |
|
G | ||||
| G1 | 18 (5.4) | 5 (27.8) | 13 (72.2) | 0.05 |
| G2 | 228 (68.3) | 118 (51.8) | 110 (48.2) | |
| G3 | 88 (26.3) | 52 (59.1) | 36 (40.9) | |
|
L | ||||
| L0 | 154 (46.1) | 76 (49.4) | 78 (50.6) | 0.357 |
| L1 | 180 (53.9) | 99 (55) | 81 (45) | |
|
V | ||||
| V0 | 238 (71.3) | 118 (49.6) | 120 (50.4) | 0.133 |
| V1 | 96 (28.7) | 57 (59.4) | 39 (40.6) | |
|
Pn | ||||
| Pn0 | 268 (80.2) | 144 (53.7) | 124 (46.3) | 0.397 |
| Pn1 | 66 (19.8) | 31 (47) | 35 (53) | |
Abbreviations: BTC=biliary tract cancer; ECC=extrahepatic cholangiocarcinoma; GBAC=adenocarcinoma of the gallbladder; ICC=intrahepatic cholangiocarcinoma; IRS=immunoreactive score; MHC I=major histocompatibility complex class I; UICC=Union for International Cancer Control.
P-values were calculated by χ2 test.