Figure 1.

Distribution of pathological responses in resected metastases. (A) Pathological response was evaluated according to the TRG score ranking digressively the importance of the response from 5 to 1 based on the amount of viable cells, necrotic zones and tumoural fibrosis. Representative images corresponding to each grade are shown. Tumour regression grades 5 and 4 correspond to an absence of response, TRG 3 to a minor response and TRG 2 and 1 to major responses. (B) For the 56 patients having multiple resected metastases, heterogeneous TRG scores of more than 2 grades disparity among their different metastases were found in 30% of the cases. (C) Pathological response was evaluated in 264 available metastases resected from 99 patients after preoperative treatment, and pR distribution was reported for each administered treatment. Significant pairwise comparisons between the various regimens are noted (P).