Table 1. The risk for gastric cancer in relation to alcohol-drinking status in the KMCC, 1994–2004.
| Total cohort (N=18 863) |
Case–cohorta (N=949) |
|||||
|---|---|---|---|---|---|---|
| Person-years | No. of cases (N=403) | HR (95% CI)b | Person-years | No. of cases (N=266) | HR (95% CI)b | |
|
Drinking status | ||||||
| Non-drinking | 129 602 | 166 | 1 (reference) | 91 801 | 107 | 1 (reference) |
| Past | 10 143 | 52 | 1.45 (0.99–2.12) | 7851 | 35 | 1.32 (0.83–2.08) |
| Current | 75 039 | 185 | 1.21 (0.94–1.56) | 55 555 | 124 | 1.02 (0.74–1.40) |
|
Duration of alcohol drinking (year) | ||||||
| Non-drinking | 129 602 | 166 | 1 (reference) | 91 801 | 107 | 1 (reference) |
| ⩽10 | 19 585 | 23 | 1.25 (0.79–1.96) | 1583 | 10 | 1.04 (0.54–2.00) |
| 11–30 | 33 378 | 54 | 0.91 (0.64–1.31) | 2773 | 27 | 0.95 (0.48–1.88) |
| 31+ | 24 393 | 134 | 1.49 (1.11–2.01) | 2375 | 86 | 1.30 (0.93–1.83) |
|
Drinking frequency (times per week) | ||||||
| Non-drinking | 129 602 | 166 | 1 (reference) | 91 801 | 107 | 1 (reference) |
| <4 | 40 198 | 80 | 1.24 (0.92–1.68) | 28 766 | 48 | 1.50 (0.87–1.81) |
| 4–6 | 13 048 | 24 | 1.00 (0.62–1.55) | 9785 | 14 | 1.28 (0.36–5.16) |
| ⩾7 | 16 684 | 76 | 1.50 (1.08–2.07) | 13 170 | 56 | 1.35 (0.96–1.88) |
|
Average alcohol-drinking dose (g per single occasion) | ||||||
| Non-drinking | 129 602 | 166 | 1 (reference) | 91 801 | 107 | 1 (reference) |
| <25 | 39 754 | 93 | 1.33 (1.01–1.77) | 24 132 | 48 | 1.22 (0.83–1.79) |
| 25–54.9 | 19 296 | 26 | 1.14 (0.72–1.80) | 7971 | 21 | 0.95 (0.56–1.60) |
| ⩾55 | 15 768 | 51 | 1.36 (0.95–1.96) | 16 867 | 44 | 1.05 (0.70–1.58) |
Abbreviations: CI=confidence interval; HR=hazard ratio; KMCC=Korean Multi-center Cancer Cohort. The bold values indicate statistical significance at 95% confidence levels.
a
Case–cohort subjects had the information of H. pylori infection.
b
Adjusted for age, sex, body mass index (BMI), educational level, and smoking status in total cohort population; adjusted for age, sex, BMI, educational level, smoking status, and H. pylori infection in case–cohort population.