Table 2. The risk for gastric cancer in relation to alcohol-drinking status according to H. pylori antibodies in the KMCC case–cohort population with the information of H. pylori antibody, 1994–2004.
|
H. pylori (+) (N=817) |
H. pylori (−) (N=132) |
|||||
|---|---|---|---|---|---|---|
| Person-years | No. of cases (N=235) | HR (95% CI)a | Person-years | No. of cases (N=31) | HR (95% CI)a | |
|
Drinking status | ||||||
| Non-drinking | 3021 | 95 | 1 (reference) | 437 | 12 | 1 (reference) |
| Past drinker | 549 | 30 | 1.32 (0.81–2.57) | 84 | 5 | 1.36 (0.37–5.01) |
| Current drinker | 3176 | 110 | 1.01 (0.72–1.48) | 432 | 14 | 1.17 (0.44–3.12) |
|
Duration of alcohol drinking (year) | ||||||
| Non-drinking | 3021 | 95 | 1 (reference) | 437 | 12 | 1 (reference) |
| ⩽10 | 318 | 10 | 1.95 (0.52–2.09) | 28 | 0 | 0.84 (0.22–3.18)b |
| 11–30 | 766 | 23 | 1.01 (0.60–1.70) | 130 | 4 | |
| 31+ | 1761 | 75 | 1.17 (0.80–1.70) | 230 | 11 | 1.65 (0.54–5.10) |
|
Alcohol-drinking frequency (times per week) | ||||||
| Non-drinker | 3021 | 95 | 1 (reference) | 437 | 12 | 1 (reference) |
| <4 | 1136 | 45 | 1.19 (0.80–1.78) | 228 | 3 | 0.21 (0.03–1.74) |
| 4–6 | 532 | 12 | 0.60 (0.31–1.14) | 71 | 2 | 1.76 (0.31–9.96) |
| ⩾7 | 1192 | 48 | 1.17 (0.78–1.77) | 102 | 8 | 3.48 (1.13–10.73)c |
|
Average alcohol-drinking dose (g per single occasion) | ||||||
| Non-drinker | 3021 | 95 | 1 (reference) | 437 | 12 | 1 (reference) |
| <25 | 993 | 43 | 1.36 (0.92–2.02) | 213 | 4 | 0.42 (0.10–2.64) |
| 25–54.9 | 583 | 18 | 0.86 (0.49–1.51) | 74 | 3 | 1.86 (0.40–3.93) |
| ⩾55 | 1153 | 39 | 0.94 (0.61–1.46) | 93 | 6 | 3.27 (1.01–10.56)c |
Abbreviations: CI=confidence interval; H. pylori=Helicobacter pylori; HR=hazard ratio; KMCC=Korean Multi-center Cancer Cohort. The bold values indicates statistical significance at 95% confidence levels.
a
Adjusted for age, sex, body mass index, educational level, and smoking status in case–cohort population.
b
The results were combined due to few events among subpopulation.
c
P-value for heterogeneity between two hazard ratio (95% CIs) in infection-positive and infection-negative groups was statistically significant (P=0.047 for drinking frequency in the groups of ‘⩾7 times per week' P=0.042 for average alcohol-drinking dose in the groups of ‘⩾55 g per day').