Table 2. Characteristics of patients and their histology in relation to the presence of each of VI, LI and PNI.
| VI not present | VI present | P-value | LI not present | LI present | P-value | PNI not present | PNI present | P-value | |
|---|---|---|---|---|---|---|---|---|---|
| Number of patients | 245 (62.2%) | 149 (37.8%) | 193 (49%) | 201 (51%) | 191 (48.5%) | 203 (51.5%) | |||
| Age | 63.5 (23–79) | 65.3(33–80) | 0.165 | 64.22 (34–79) | 64 (23–80) | 0.165 | 64.3 (23–79) | 63.9 (33–80) | 0.286 |
| Male | 179 (61%) | 114 (39%) | 138 (47.1%) | 155 (52.9%) | 140 (47.8%) | 153 (52.2%) | |||
| Female | 66 (65.3%) | 35 (34.7%) | 0.447 | 55 (54.4%) | 46 (45.6%) | 0.202 | 51 (50.5%) | 50 (49.5%) | 0.638 |
|
Histology | |||||||||
| Adenocarcinoma | 183 (60.6%) | 119 (39.4%) | 135 (44.7%) | 167 (55.3%) | 133 (44%) | 169 (56%) | |||
| Squamous cell carcinoma | 62 (67.4%) | 30 (32.6%) | 0.239 | 58 (63%) | 34 (37%) | 0.002 | 58 (63%) | 34 (37%) | 0.001 |
|
Tumour location | |||||||||
| Mid oesophagus | 29 (67.4%) | 14 (32.6%) | 32 (74.4%) | 11 (25.6%) | 27 (62.8%) | 16 (37.2%) | |||
| Lower oesophagus | 105 (65.6%) | 55 (34.4%) | 86 (53.8%) | 74 (46.2%) | 82 (51.3%) | 78 (48.7%) | |||
| GOJ | 111 (58.1%) | 80 (41.9%) | 0.265 | 75 (39.3%) | 116 (60.7%) | <0.001 | 82 (42.9%) | 109 (57.1%) | 0.041 |
|
Pretreatment T stage | |||||||||
| T1 | 2 (66.7%) | 1 (33.3%) | 2 (66.7%) | 1 (33.3%) | 2 (66.7%) | 1 (33.3%) | |||
| T2 | 14 (66.7%) | 7 (33.3%) | 13 (61.9%) | 8 (38.1%) | 17 (81.0%) | 4 (19%) | |||
| T3 | 213 (61.6%) | 133 (38.4%) | 168 (48.6%) | 178 (51.4%) | 161 (45.2%) | 185 (54.8%) | |||
| T4 | 13 (61.9%) | 8 (38.1%) | 7 (33.3%) | 14 (66.7%) | 9 (42.9%) | 12 (57.1%) | |||
| Tx | 3 (100%) | 0 (0%) | 0.72 | 3 (100%) | 0 (0%) | 0.137 | 2 (66.7%) | 1 (33.3%) | 0.033 |
|
Pretreatment N Stage | |||||||||
| N0 | 25 (67.6%) | 12 (32.4%) | 17 (45.9%) | 20 (54.1%) | 11 (29.7%) | 26 (70.3%) | |||
| N1 | 171 (62.4%) | 103 (37.6%) | 129 (47.1%) | 145 (52.9%) | 132 (48.2%) | 142 (51.8%) | |||
| N2 | 39 (60%) | 26 (40%) | 35 (53.8%) | 30 (46.2%) | 37 (56.9%) | 28 (43.1%) | |||
| N3 | 8 (53.3%) | 7 (46.7%) | 10 (66.7%) | 5 (33.3%) | 8 (53.3%) | 7 (46.7%) | |||
| Nx | 2 (66.7%) | 1 (33.3%) | 0.891 | 2 (66.7%) | 1 (33.3) | 0.493 | 3 (100%) | 0 (0%) | 0.034 |
|
Radicality | |||||||||
| R0 | 240 (62.2%) | 146 (37.8%) | 189 (49%) | 197 (51%) | 189 (49%) | 197 (51%) | |||
| R1 | 5 (62.5%) | 3 (37.5%) | 0.985 | 4 (50%) | 4 (50%) | 1 | 2 (25%) | 6 (75%) | 1 |
| Number of resected nodes | 33 (11–77) | 32 (10–64) | 0.787 | 31 (11–77) | 35 (10–75) | 0.003 | 32 (22–77) | 33 (10–72) | 0.532 |
| Number of positive nodes | 0 (0–13) | 3 (0–35) | <0.001 | 0 (0–12) | 3 (0.35) | <0.001 | 0 (0–18) | 3 (0–35) | 0.532 |
|
Post-treatment T stage | |||||||||
| ypT0 | 17 (100%) | 0 (0%) | 17 (100%) | 0 (0%) | 17 (100%) | 0 (0%) | |||
| ypT1 | 41 (85.4%) | 7 (14.6%) | 40 (83.3%) | 8 (16.7%) | 47 (97.9%) | 1 (2.1%) | |||
| ypT2 | 55 (73.3%) | 20 (26.7%) | 41 (54.7%) | 34 (45.3%) | 55 (73.3%) | 20 (26.7%) | |||
| ypT3 | 128 (53.8%) | 110 (46.2%) | 90 (37.8%) | 148 (62.2%) | 71 (29.8%) | 167 (70.2%) | |||
| ypT4 | 4 (25%) | 12 (75%) | <0.001 | 5 (31.3%) | 11 (68.7%) | <0.001 | 1 (6.3%) | 15 (93.7%) | <0.001 |
|
Post-treatment N stage | |||||||||
| ypN0 | 131 (81.9%) | 29 (18.1%) | 119 (74.4%) | 41 (25.6%) | 116 (72.5%) | 44 (27.5%) | |||
| ypN1 | 54 (65.1%) | 29 (34.9%) | 43 (51.8%) | 40 (48.2%) | 42 (50.6%) | 41 (49.4%) | |||
| ypN2 | 36 (45%) | 44 (55%) | 21 (26.3%) | 59 (73.7%) | 24 (30%) | 56 (70%) | |||
| ypN3 | 24 (33.8%) | 47 (66.2%) | <0.001 | 10 (14.1%) | 61 (85.9%) | <0.001 | 9 (12.7%) | 62 (87.3%) | <0.001 |
| LI present | 83 (41.3%) | 118 (58.7%) | <0.001 | NA | NA | 54 (26.9%) | 147 (73.3%) | <0.001 | |
| PNI present | 93 (45.8%) | 110 (54.2%) | <0.001 | 56 (27.6%) | 147 (82.4%) | <0.001 | NA | NA | |
| VI present | NA | NA | 31 (20.8%) | 118 (79.2%) | <0.001 | 39 (26.2%) | 110 (73.8%) | <0.001 | |
Abbreviations: GOJ=gastro-oesophageal junction; LI=lymph vessel invasion; PNI=perineural invasion; VI=venous invasion. The bold entries are those that are statistically significant