Table 3. Uni- and multivariate analysis of prognostic factors for disease-free survival in patients with cancer of the oesophagus or GOJ who underwent neoadjuvant chemoradiation therapy followed by a transthoracic oesophagectomy.

	Median survival (95% confidence interval)	P-value univariatea	P-value multivariate
Age
<65	37.98 (29.09–46.87)	0.676	—
⩾65	40.90 (15.20–66.60)
Sex
Male	97.31 (57.8–136.83)	0.005	0.006
Female	32.89 (26.54–39.24)
Histology type
Adeno	35.29 (27.22–43.35)	0.054	0.030
Squamous cell	65.61 (28.39–102.83)
Tumour location
Mid oesophagus	98.10 (35.12–161.09)	0.145	—
Distal oesophagus	37.98 (21.17–54.80)
GOJ	34.43 (24.32–44.54)
Radicality
R0	40.9 (26.60–55.21)	0.001	0.002
R1	12.62 (11.86–13.38)
Post-treatment T stage (ypT)
ypT0	150.68 (111.72–182.66)	<0.001	0.150
ypT1	97.31 (77.91–116.72)
YpT2	78.48 (66.39–90.57)
ypT3	28.55 (24.01–33.09)
ypT4	7.52 (3.09–11.96)
Post-treatment N stage (ypN)
ypN0	170.84 (72.27–269.41)	<0.001	<0.001
ypN1	66.07(15.94–116.20)
ypN2	24.25 (17.03–31.46)
ypN3	13.21 (9.93–16.49)
The presence of VI, LI and PNI
No presence	170.84 (69.94–272.75)	<0.001	0.007
One factor present	40.90 (19.95–61.86)
Two factors present	27.11 (22.76–31.45)
Three factors present	16.33 (10.27–22.39)

Abbreviations: GOJ=gastro-oesophageal junction; LI=lymph vessel invasion; PNI=perineural invasion; R0=microscopically radical resection; R1=microscopically tumour left behind; VI=venous invasion. The bold entries are those that are statistically significant.

^aLog-rank test.