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. 2015 Nov 10;113(10):1477–1483. doi: 10.1038/bjc.2015.369

Table 2. Association between CDK4/6SA and various clinicopathological backgrounds, including Ki-67 expression.

    CDK4/6SA  
Parameter Criteria ⩽4.8 >4.8 P-value
Age <60 35 33 0.845
  ⩾60 20 21  
Stage ⩽II 36 41 0.293
  ⩾III 19 13  
Lymph-node metastasis No 44 44 0.760
  Yes 7 5  
Histological grade I 34 41 0.140
  II&III 20 12  
Tumour size <5 cm 30 30 1.000
  ⩾5 cm 22 23  
Myometrial invasion ⩽1/2 44 43 0.798
  >1/2 10 8  
Vascular invasion No 41 44 0.474
  Yes 13 9  
Lymphatic invasion No 40 44 0.347
  Yes 14 9  
CDK4 IHC average score <1.0 25 25 0.928
  ⩾1.0 28 25  
Ki-67 IHC average score <1.5 12 22 0.035
  ⩾1.5 41 28  

Abbreviations: CDK4=cyclin-dependent kinase 4; CDK4/6SA=CDK4/6-specific activity; IHC=immunohistochemistry.Bold entries denote P<0.05 (significant).