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. 2015 Nov 10;113(10):1477–1483. doi: 10.1038/bjc.2015.369

Table 3. Uni/Multivariate analysis of CDK4/6SA in combination with Ki-67 in low-risk patients.

    Univariate analysis
Multivariate analysis
Parameter Criteria HR 95% CI P-value HR 95% CI P-value
Age >60 2.00 0.150–8.85 0.336      
  ⩽60            
Stage ⩽II 3.40 0.414–28.1 0.256      
  ⩾III            
Vascular invasion No 3.00 0.583–15.2 0.192 1.59 0.248–10.2 0.628
  Yes            
Histological grade I 2.30 0.209–10.0 0.287      
  II and III            
Tumour size <5 cm 2.70 0.618–12.2 0.187 2.86 0.508–16.1 0.236
  ⩾5 cm            
Myometrial invasion ⩽1/2 0.90 0.167–4.36 0.849      
  >1/2            
Lymphatic invasion No 1.50 0.180–12.2 0.716      
  Yes            
CDK4-IHC <1.5 1.60 0.624–4.12 0.328      
  ⩾1.5            
CDK4/6SA and Ki-67 High and high 11.80 1.44–97.3 0.022 11.39 1.23–105 0.033
  Others            

Abbreviations: CDK4=cyclin-dependent kinase 4; CDK4/6SA=CDK4/6-specific activity; IHC=immunohistochemistry. Bold entries denote HR>10 or P<0.2 (significant). Italic entries indicate P<0.05 (significant).