Table 3. Uni/Multivariate analysis of CDK4/6SA in combination with Ki-67 in low-risk patients.

		Univariate analysis			Multivariate analysis
Parameter	Criteria	HR	95% CI	P-value	HR	95% CI	P-value
Age	>60	2.00	0.150–8.85	0.336
	⩽60
Stage	⩽II	3.40	0.414–28.1	0.256
	⩾III
Vascular invasion	No	3.00	0.583–15.2	0.192	1.59	0.248–10.2	0.628
	Yes
Histological grade	I	2.30	0.209–10.0	0.287
	II and III
Tumour size	<5 cm	2.70	0.618–12.2	0.187	2.86	0.508–16.1	0.236
	⩾5 cm
Myometrial invasion	⩽1/2	0.90	0.167–4.36	0.849
	>1/2
Lymphatic invasion	No	1.50	0.180–12.2	0.716
	Yes
CDK4-IHC	<1.5	1.60	0.624–4.12	0.328
	⩾1.5
CDK4/6SA and Ki-67	High and high	11.80	1.44–97.3	0.022	11.39	1.23–105	0.033
	Others

Abbreviations: CDK4=cyclin-dependent kinase 4; CDK4/6SA=CDK4/6-specific activity; IHC=immunohistochemistry. Bold entries denote HR>10 or P<0.2 (significant). Italic entries indicate P<0.05 (significant).