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. 2016 Mar 31;4:31. doi: 10.3389/fped.2016.00031

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Copyright © 2016 Kimura, Saravia, Rovnaghi, Meduri, Schwingshackl, Cormier and Anand.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparisons of biomarker levels between placebo and the MPT groups on days 0 and 7. There are no differences between cytokine levels detected in MPT and control groups on day 0 or day 7. Two-tailed unpaired t or u test dependent were used dependent upon variances differences evaluated by F test. On day 7, we observed a significant reduction in plasma levels of MMP-8 (p = 0.0016) in the MPT and a significant increase in plasma levels of sICAM-1 (p = 0.0005) in the placebo group (MPT group had no increase by day 7). Levels of sRAGE decreased significantly in both the MPT and placebo groups (p < 0.002) from day 0 to day 7. A p-value of <0.05 was considered significant (*).