Table 1.
Significant results from comparison of biomarker levels within the placebo and the MPT groups between days 0 and 7.
| N | Median | 25% percentile | 75% percentile | Mean | SD | SEM | Two-tailed Mann–Whitney | Two-tailed unpaired t-test | |
|---|---|---|---|---|---|---|---|---|---|
| MPT, day 0: MMP-8 (ng/ml) | 15 | 12 | 6.4 | 23 | 20 | 25 | 6.3 | 0.0016 | |
| MPT, day 7: MMP-8 (ng/ml) | 6 | 0.63 | 0.28 | 4.8 | 2.1 | 2.7 | 1.1 | ||
| MPT, day 0: sRAGE (pg/ml) | 15 | 356 | 244 | 535 | 1,085 | 2,495 | 644 | 0.0007 | |
| MPT, day 7: sRAGE (pg/ml) | 6 | 74 | 16 | 136 | 79 | 62 | 25 | ||
| P, day 0: ICAM-1 (pg/ml) | 18 | 13,814 | 8,444 | 17,783 | 13,973 | 5,453 | 1,285 | 0.0005 | |
| P, day 7: ICAM-1 (pg/ml) | 7 | 24,824 | 16,710 | 30,346 | 24,461 | 6,859 | 2,592 | ||
| P, day 0: sRAGE (pg/ml) | 18 | 376 | 152 | 2,941 | 1,599 | 2,346 | 553 | 0.0018 | |
| P, day 7: sRAGE (pg/ml) | 7 | 77 | 29 | 131 | 79 | 49 | 19 | ||
| A-S, day 0: MMP-8 (ng/ml) | 32 | 10 | 3.9 | 23 | 19 | 25 | 4.4 | 0.0007 | |
| A-S, day 7: MMP-8 (ng/ml) | 13 | 1.9 | 0.47 | 5.1 | 3.1 | 3.1 | 0.86 | ||
| A-S, day 0: sRAGE (pg/ml) | 33 | 363 | 196 | 1,209 | 1,365 | 2,390 | 416 | <0.0001 | |
| A-S, day 7: sRAGE (pg/ml) | 13 | 77 | 26 | 127 | 79 | 53 | 15 |
Table of within-treatment group statistical differences, comparing days 0 to 7 levels of MMP-8, sRAGE, and ICAM-1. Day 0 compared to day 7 levels of PAI-1 and angiopoietin-2 did not differ. Methylprednisolone group (MPT), placebo group (P), all subjects (A-S), SD, and SEM.