Table 2.

Major interacting proteins with increased binding to the HER2 mutants compared to HER2‐wt.

Protein identified	Name	Function
HSP90A	Heat shock 90 kDa protein alpha	Chaperone
HSP70 ½	Heat shock 70 kDa protein 1/2	Chaperone
HSP27	Heat shock protein 27	Chaperone
HSP40	DnaJ (Hsp40) homolog, subfamily C, member10	Co‐chaperone
CDC37	HSP90‐cochaperone CDC37	Co‐chaperone
BAG2	BAG family molecular chaperone regulator 2	Co‐chaperone
MIF	Macrophage migration inhibitory factor	Cytokine

a Exogenous c‐myc‐tagged HER2 over‐expressed in MCF10A cells was pulled‐down with a c‐myc antibody and then analyzed using mass spectrometry.