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Illustrative model of Rac1's role in uterine epithelial function during embryo implantation. During receptivity establishment, uterine Rac1 via Pak1-ERM signaling cascade ensures normal luminal epithelial integrity conducive to on-time embryo implantation; while during postimplantation uterine development, Rac1 mediates TNFα induced luminal epithelium elimination via P38 MAPK signaling cascade, which is required for trophoblast invasion into the uterine bed
