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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Ultrasound Med Biol. 2015 Nov 23;42(2):481–492. doi: 10.1016/j.ultrasmedbio.2015.10.009

Table 4.

Effects observed on histopathology and magnetic resonance imaging of the sixth blood–brain barrier disruption session

Animal ID Weight week 6, g Acoustic pressure, MPa Histopathology MRI
ΔSI (%) T2-WI
1 455 0.73 No effects 37.1 Light hyper-intensity
2 426 0.73 No effects 13.1 -
3 362 0.73 A few tiny micro-hemorrhages 31.5 Light hyper-intensity
4 370 0.73 A few tiny micro-hemorrhages 22.7 Light hyper-intensity
5 425 0.73 Micro-hemorrhages 28.7 Light hyper-intensity
6 430 0.73 Micro-hemorrhages 8.2 -
7 420 0.73 No effects 5.3 -
8 400 0.73 A few tiny micro-hemorrhages 15.7 Light hyper-intensity
9 490 0.73 No effects 42.9 Light hyper-intensity
10 470 0.73 No effects 17.6 -
11 374 0.80 Micro-hemorrhages + selective neuronal necrosis 38.0 -
12 389 0.80 Micro-hemorrhages + selective neuronal necrosis 15.6 NA*
13 401 0.80 Multiple extensive micro-hemorrhages 16.8 Light hyper-intensity
14 398 0.80 Micro-hemorrhages + selective neuronal necrosis 12.8 Light hyper-intensity
15 473 0.80 Hemorrhagic infarct 71.5 Light hyper-intensity

MRI = magnetic resonance imaging; ΔSI = difference in signal intensity change in pre- and post-sonication T1-WI.

*

NA = data not available.