Table 4.
Animal ID | Weight week 6, g | Acoustic pressure, MPa | Histopathology | MRI
|
|
---|---|---|---|---|---|
ΔSI (%) | T2-WI | ||||
1 | 455 | 0.73 | No effects | 37.1 | Light hyper-intensity |
2 | 426 | 0.73 | No effects | 13.1 | - |
3 | 362 | 0.73 | A few tiny micro-hemorrhages | 31.5 | Light hyper-intensity |
4 | 370 | 0.73 | A few tiny micro-hemorrhages | 22.7 | Light hyper-intensity |
5 | 425 | 0.73 | Micro-hemorrhages | 28.7 | Light hyper-intensity |
6 | 430 | 0.73 | Micro-hemorrhages | 8.2 | - |
7 | 420 | 0.73 | No effects | 5.3 | - |
8 | 400 | 0.73 | A few tiny micro-hemorrhages | 15.7 | Light hyper-intensity |
9 | 490 | 0.73 | No effects | 42.9 | Light hyper-intensity |
10 | 470 | 0.73 | No effects | 17.6 | - |
11 | 374 | 0.80 | Micro-hemorrhages + selective neuronal necrosis | 38.0 | - |
12 | 389 | 0.80 | Micro-hemorrhages + selective neuronal necrosis | 15.6 | NA* |
13 | 401 | 0.80 | Multiple extensive micro-hemorrhages | 16.8 | Light hyper-intensity |
14 | 398 | 0.80 | Micro-hemorrhages + selective neuronal necrosis | 12.8 | Light hyper-intensity |
15 | 473 | 0.80 | Hemorrhagic infarct | 71.5 | Light hyper-intensity |
MRI = magnetic resonance imaging; ΔSI = difference in signal intensity change in pre- and post-sonication T1-WI.
NA = data not available.