Table 1.
Treatment-related effects of polybrominated diphenyl ether, male rats, week 13
| Dose group (mg/kg) |
Males 0 |
Males 50 |
Females 0 |
Females 50 |
|---|---|---|---|---|
| Hepatocyte hypertrophy | 0/10 | 10/10 (3.1)a |
0/10 | 10/10 (2.9) |
| Hepatocyte vacuolization | 3/10 (1.0) |
10/10 (1.2) |
2/10 (1.0) |
4/10 (1.0) |
| Thyroid gland Follicle hypertrophy |
0/10 | 5/10 (1.2) |
0/10 | 5/10 (1.2) |
| Mean body wt (gms) | 403.4 | 431.2 | 245.6 | 213.3 |
| Mean liver wt (gms) | 13.7 ± 1.24 | 19.5 ±2.39 | 7.94± 0.58 | 9.28 ± 1.35 |
a
Lesions severity grade