Table 3.
Selected liver gene transcript changes in postnatal day 22 male pup livera
| AffyProbe Set ID |
Gene Symbol |
GeneName | Fold Change Male pups |
Fold change Female Pups |
|---|---|---|---|---|
|
Up regulation of genes combating oxidative stress |
||||
| “1387958_at” | “Akr1c18” | “aldo-keto reductase family 1, member C18” |
2.38 | 1.78 |
| “1371997_at” | “Akr1cl2” | “aldo-keto reductase family 1, member C-like 2” |
1.34 | 1.24 |
| “1398310_at” | “Akr1d1” | “aldo-keto reductase family 1, member D1 (delta 4–3-ketosteroid-5- beta-reductase)” |
1.42 | 1.16 |
| “1367843_at” | “Akr7a2” | “aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)” |
1.39 | 1.46 |
| “1368121_at” | “Akr7a3” | “aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)” |
3.04 | 2.40 |
| “1387022_at” | “Aldh1a1” | “aldehyde dehydrogenase 1 family, member A1” |
2.84 | 2.87 |
| “1368718_at” | “Aldh1a7” | “aldehyde dehydrogenase family 1, subfamily A7” |
2.78 | 2.65 |
| “1368130_at” | “Aldh3a1” | “aldehyde dehydrogenase 3 family, member A1” |
1.88 | 4.81 |
| “1368037_at” | “Cbr1” | “carbonyl reductase 1” | 1.43 | 1.52 |
| “1367774_at” | “Gsta3” | “glutathione S -transferase A3” |
1.30 | 1.22 |
| “1372297_at” | “Gsta4” | “glutathione S- transferase alpha 4” |
2.45 | 2.27 |
| “1386985_at” | “Gstm1” | “glutathione S- transferase mu 1” |
1.70 | 1.71 |
| “1370952_at” | “Gstm2” | “glutathione S- transferase mu 2” |
2.65 | 2.02 |
| “1369921_at” | “Gstm3” | “glutathione S- transferase mu 3” |
2.01 | 1.71 |
| “1375909_at” | “Gstm4” | “glutathione S- transferase mu 4” |
1.74 | 1.77 |
| “1368354_at” | “Gstt1” | “glutathione S- transferase theta 1” |
1.74 | 1.62 |
| “1371942_at” | “Gstt3” | “glutathione S- transferase, theta 3” |
1.96 | 1.73 |
| “1372599_at” | “Mgst2” | “microsomal glutathione S-transferase 2” |
1.45 | 1.46 |
|
Genes in lipid metabolism/ metabolic syndrome |
||||
| “1368126_at” | “Aacs” | “acetoacetyl-CoA synthetase” |
−3.51 | −2.70 |
| “1369455_at” | “Abcg5” | “ATP-binding cassette, sub-family G (WHITE), member 5” |
−4.57 | −4.24 |
| “1368718_at” | “Aldh1a7” | “aldehyde dehydrogenase family 1, subfamily A7” |
2.78 | 2.65 |
| “1369727_at” | “Apoa2” | “apolipoprotein A-II” | 3.64 | 3.79 |
| “1369011_at” | “Apoa5” | “apolipoprotein A-V” | −1.50 | −1.60 |
| “1393139_at” | “Apoc2” | “apolipoprotein C-II” | −1.23 | −1.11 |
| “1386901_at” | “Cd36” | “CD36 molecule (thrombospondin receptor)” |
1.66 | −1.06 |
| “1367689_a_at” | “Cd36” | “CD36 molecule (thrombospondin receptor)” |
1.26 | - |
| “1384341_at” | “Faah” | “fatty acid amide hydrolase” |
−1.52 | - |
| “1393751_at” | “Fabp12” | “fatty acid binding protein 12” |
−1.62 | - |
| “1370281_at” | “Fabp5” | “fatty acid binding protein 5, epidermal” |
−2.84 | - |
| “1370024_at” | “Fabp7” | “fatty acid binding protein 7, brain” |
−1.38 | - |
| “1368453_at” | “Fads2” | “fatty acid desaturase 2” | −2.97 | −1.94 |
| “1372476_at” | “Fads3” | “fatty acid desaturase 3” | 1.56 | - |
| “1367707_at” | “Fasn” | “fatty acid synthase” | −2.99 | - |
| “1367708_a_at” | “Fasn” | “fatty acid synthase” | −2.17 | - |
| “1373491_at” | “Gba” | “glucosidase, beta, acid” | 1.44 | 1.34 |
| “1370200_at” | “Glud1” | “glutamate dehydrogenase 1” |
−1.46 | - |
| “1373222_at” | “Hexa” | “hexosaminidase A” | 1.32 | - |
| “1375852_at” | “Hmgcr” | “3-hydroxy-3- methylglutaryl- Coenzyme A reductase” |
−1.70 | - |
| “1387848_at” | “Hmgcr” | “3-hydroxy-3- methylglutaryl- Coenzyme A reductase” |
−1.78 | - |
| “1367648_at” | “Igfbp2” | “insulin-like growth factor binding protein 2” |
−5.17 | −2.51 |
| “1367887_at” | “Lcat” | “lecithin cholesterol acyltransferase” |
−1.14 | - |
| “1381672_at” | “Ldlrap1” | “low density lipoprotein receptor adaptor protein 1” |
1.10 | - |
| “1386965_at” | “Lpl” | “lipoprotein lipase” | 7.13 | 4.71 |
| “1369150_at” | “Pdk4” | “pyruvate dehydrogenase kinase, isozyme 4” |
1.88 | - |
| “1386864_at” | “Pgam1” | “phosphoglycerate mutase 1 (brain)” |
1.25 | 1.26 |
| “1387803_at” | “Ppp2r2b” | “protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform” |
−4.83 | −6.34 |
| “1371143_at” | “Serpina7” | “serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7” |
−4.53 | −4.44 |
| “1387325_at” | “Slc27a5” | “solute carrier family 27 (fatty acid transporter), member 5” |
−1.56 | −1.49 |
| “1369636_at” | “Sord” | “sorbitol Dehydrogenase” |
1.29 | - |
| “1394786_at” | “Sorl1” | “sortilin-related receptor, LDLR class A repeats- containing” |
−1.44 | - |
| “1393933_at” | “Sorl1” | “sortilin-related receptor, LDLR class A repeats- containing” |
−1.44 | - |
| “1371104_at” | “Srebf1” | “sterol regulatory element binding transcription factor 1” |
−1.87 | - |
| “1371979_at” | “Srebf2” | “sterol regulatory element binding transcription factor 2” |
−1.31 | - |
| “1367938_at” | “Ugdh” | “UDP-glucose dehydrogenase” |
1.67 | 1.49 |
| “1389611_at” | “Vldlr” | “very low density lipoprotein receptor” |
−1.03 | 1.32 |
|
Cytochrome P450s |
||||
| 1369136_at | Cyp2a3a | cytochrome P450, family 2, subfamily A, polypeptide 3a |
37.40 | 6.84 |
| 1370269_at | Cyp1a1 | cytochrome P450, family 1, subfamily a, polypeptide 1 |
26.68 | 39.63 |
| 1370241_at | Cyp2c7 | cytochrome P450, family 2, subfamily c, polypeptide 7 |
23.68 | 9.17 |
| 1370495_s_at | Cyp2c13 | cytochrome P450 2c13 | 21.10 | - |
| 1387328_at | Cyp2c | cytochrome P450, subfamily IIC (mephenytoin 4- hydroxylase) |
6.99 | 2.45 |
| 1368990_at | Cyp1b1 | cytochrome P450, family 1, subfamily b, polypeptide 1 |
4.95 | 10.96 |
| 1370387_at | Cyp3a9 | cytochrome P450, family 3, subfamily a, polypeptide 9 |
2.95 | - |
| 1387243_at | Cyp1a2 | cytochrome P450, family 1, subfamily a, polypeptide 2 |
2.24 | 2.13 |
| 1387118_at | Cyp3a23/3a1 | cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1 |
1.97 | 2.03 |
| 1369424_at | Cyp2a2 | cytochrome P450, subfamily 2A, polypeptide 1 |
1.77 | - |
| 1387511_at | Cyp2a1 | cytochrome P450 IIA1 (hepatic steroid hydroxylase IIA1) gene |
1.64 | - |
| 1368155_at | Cyp2c12 | cytochrome P450, family 2, subfamily c, polypeptide 12 |
1.52 | - |
| 1387296_at | Cyp2j4 | cytochrome P450, family 2, subfamily J, polypeptide 4 |
1.46 | - |
| 1387296_at | Cyp2j4 | cytochrome P450, family 2, subfamily J, polypeptide 4 |
1.46 | - |
| 1387973_at | Cyp4f4 | cytochrome P450, family 4, subfamily f, polypeptide 4 |
1.28 | - |
| 1371142_at | Cyp2g1 | cytochrome P450, subfamily 2G, polypeptide 1 |
−1.03 | - |
| 1368458_at | Cyp7a1 | cytochrome P450, family 7, subfamily a, polypeptide 1 |
−2.30 | - |
| 1368435_at | Cyp8b1 | cytochrome P450, family 8, subfamily b, polypeptide 1 |
−2.93 | −4.20 |
| 1387123_at | Cyp17a1 | cytochrome P450, family 17, subfamily a, polypeptide 1 |
−6.16 | −5.23 |
| 1371076_at | Cyp2b | cytochrome P450, family 2b |
6.13 | 9.96 |
|
Cell cycle/cancer |
||||
| “1369698_at” | “Abcc3” | “ATP-binding cassette, sub-family C (CFTR/MRP), member 3” |
3.23 | 3.23 |
| “1379652_at” | “Ahctf1” | “AT hook containing transcription factor 1” |
−1.54 | - |
| “1379652_at” | “Ahctf1” | “AT hook containing transcription factor 1” |
−1.54 | - |
| “1369983_at” | “Ccl5” | “chemokine (C-C motif) ligand 5” |
2.21 | 2.02 |
| “1370345_at” | “Ccnb1” | “cyclin B1” | 1.94 | - |
| “1389566_at” | “Ccnb2” | “cyclin B2” | 1.78 | - |
| “1371643_at” | “Ccnd1” | “cyclin D1” | −2.13 | - |
| “1371150_at” | “Ccnd1” | “cyclin D1” | −2.28 | −1.94 |
| “1383075_at” | “Ccnd1” | “cyclin D1” | −2.33 | −2.1 |
| “1370810_at” | “Ccnd2” | “cyclin D2” | −1.42 | - |
| “1371953_at” | “Ccng2” | “cyclin G2” | 2.33 | - |
| “1380997_at” | “Ccnj” | “cyclin J” | −1.51 | - |
| “1374220_at” | “Ccny” | “cyclin Y” | 1.33 | - |
| “1372685_at” | “Cdkn3” | “cyclin-dependent kinase inhibitor 3” |
1.79 | - |
| “1387062_a_at” | “Chek1” | “CHK1 checkpoint homolog (S. pombe)” |
2.90 | 3.89 |
| “1367515_at” | “Cnot7” | “CCR4-NOT transcription complex, subunit 7” |
−1.31 | - |
| “1367515_at” | “Cnot7” | “CCR4-NOT transcription complex, subunit 7” |
−1.31 | - |
| “1368174_at” | “Egln3” | “EGL nine homolog 3 (C. elegans)” |
4.43 | 4.89 |
| “1373011_at” | “Fam134b” | “family with sequence similarity 134, member B” |
4.34 | 3.87 |
| “1368408_at” | “Grk5” | “G protein-coupled receptor kinase 5” |
3.28 | 2.95 |
| “1368549_at” | “Hbp1” | “HMG-box transcription factor 1” |
1.30 | - |
| “1368549_at” | “Hbp1” | “HMG-box transcription factor 1” |
1.30 | - |
| “1370728_at” | “Il13ra1” | “interleukin 13 receptor, alpha 1” |
1.73 | - |
| “1388711_at” | “Il13ra1” | “interleukin 13 receptor, alpha 1” |
1.47 | - |
| “1371170_a_at” | “Il1a” | “interleukin 1 alpha” | −1.37 | −1.59 |
| “1368592_at” | “Il1a” | “interleukin 1 alpha” | −1.75 | - |
| “1387394_at” | “Il2rb” | “interleukin 2 receptor, beta” |
1.50 | - |
| “1387935_at” | “Il3ra” | “interleukin 3 receptor, alpha” |
1.39 | 1.34 |
| “1386987_at” | “Il6ra” | “interleukin 6 receptor, alpha” |
−1.33 | - |
| “1373379_at” | “Irak1” | “interleukin-1 receptor- associated kinase 1” |
1.32 | - |
| “1380336_at” | “Irak3” | “interleukin-1 receptor- associated kinase 3” |
1.50 | - |
| “1368915_at” | “Kmo” | “kynurenine 3- Monooxygenase (kynurenine 3- hydroxylase)” |
−1.54 | −0.02 |
| “1371479_at” | “Mettl7a” | “methyltransferase like 7A” |
1.90 | 1.54 |
| “1384280_at” | “Nusap1” | “nucleolar and spindle associated protein 1” |
1.59 | - |
| “1392715_at” | “Ppargc1b” | “peroxisome proliferator-activated receptor gamma, coactivator 1 beta” |
−1.82 | - |
| “1370012_at” | “Ptgis” | “prostaglandin I2 (prostacyclin) synthase” |
−3.10 | −3.19 |
| “1398814_at” | “Rab11a” | “RAB11a, member RAS oncogene family” |
1.40 | 1.37 |
| “1389066_at” | “Rcan2” | “regulator of calcineurin 2” |
2.10 | 2.15 |
| “1378605_at” | “Sigirr” | “single immunoglobulin and toll-interleukin 1 receptor (TIR) domain” |
1.32 | - |
| “1379275_at” | “Snx10” | “sorting nexin 10” | 3.96 | 5.49 |
| “1371104_at” | “Srebf1” | “sterol regulatory element binding transcription factor 1” |
−1.87 | - |
| “1388426_at” | “Srebf1” | “sterol regulatory element binding transcription factor 1” |
−1.94 | - |
| “1367941_at” | “Tfam” | “transcription factor A, mitochondrial” |
1.04 | - |
| “1376668_at” | “Ttc39a” | “tetratricopeptide repeat domain 39A” |
8.84 | 14.87 |
a
False discovery rate < 0.01; p < .01 for all gene transcripts in this table (complete details in supplements 1 and 2). Most of these gene transcripts were not significantly changed in week13 male rat livers.