Table 2. The T300A variants of ATG16L1 association with penetrations, immunosuppressive medication, intra-abdominal abscess, and postsurgical infections.

	GG risk variant	AA+AG genotype	P	OR (95% CI)
Penetrating disease	56	52	0.18	0.70 (0.40–1.20)
Non-penetrating disease	52	76
Immunosuppressive medication	17	11	0.15	0.58 (0.25–1.31)
No immunosuppressive medication	91	117
Intra-abdominal abscess	32	26	0.29	0.71 (0.38–1.34)
No intra-abdominal abscess	76	102
Postsurgical serious infections	6	3	0.08	3.56 (0.86–14.69)
No postsurgical serious infections	68	121

ATG16L1, autophagy-related 16-like 1; CI, confidence interval; OR, odds ratio.

AA, AG, and GG represent the genotype of ATG16L1.

The correlations between the frequencies of ATG16L1 genotypes (AA+AG and GG) and postsurgical serious infections were analyzed using 2x2 contingency tables (Fisher's exact test). The logistic regression was used to examine any association between ATG16L1 genotypes and other clinical data obtained from patient charts and to calculate age, gender, phenotype, and duration-adjusted ORs and 95% CIs. A two-tailed P value <0.05 was considered significant.

The denominator is different in the individual 2 × 2 tables, as postsurgical infections were related to the total number of intra-abdominal surgical procures performed within the group, whereas the other categories were related to the total number of patients with the specific gene variants.