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. 2015 Dec 28;8(2):144–156. doi: 10.1093/jmcb/mjv066

Figure 1.

Figure 1

ER stress preconditioning alleviates hepatic I/R injury in rats. (A and B) Serum ALT/AST levels at different time points after I/R injury with or without ER stress preconditioning (administration of TM, 100 µg/kg body weight at 5 days before surgery). Blood samples were drawn through a tail vein of the rats at indicated time points and prepared for analysis. ALT and AST levels are presented in units/L and expressed as mean ± SD. *P < 0.05. (C) H&E staining of liver specimens. Representative images of each group are shown. Vehicle Sham, sham-operated group dosed with saline; TM Sham, sham-operated group dosed with TM; Vehicle I/R, partial hepatic I/R group dosed with saline; TM I/R, partial hepatic I/R group dosed with TM (ER stress preconditioning followed by hepatic I/R injury). Liver samples were obtained at 24 h after surgery and prepared for H&E staining. Upper panel, 40× magnification; lower panel, 200× magnification. (D) The quantitative analysis of the liver injury scores. H&E staining of liver specimens were assessed for histological scores. Values are expressed as means ± SD. NS, no significant difference. *P < 0.05 compared with the sham group; #P < 0.05 compared with the I/R group.