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. 2016 Jan 14;7(1):e2058. doi: 10.1038/cddis.2015.275

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Copyright © 2016 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The mitochondria-mediated intrinsic (a) and death receptor-mediated extrinsic (b) pathway. Apaf-1, apoptotic protease activating factor 1; FADD, Fas-associated death domain; TRADD, TNFR-associated death domain protein