Table 1. BCL-2 protein family members and their function.

BCL-2 family member	BH domain	Proapoptotic	Antiapoptotic	Proapoptotic function type
BCL-2	BH 1–4		√	None
BCL-xL	BH 1–4		√	None
BCL-w	BH 1–4		√	None
BFL-1	BH 1–4		√	None
MCL-1	BH 1–4		√	None
BAX	BH 1–3	√		Effector
BAK	BH 1–3	√		Effector
BIM	BH3-only	√		Activator
BID	BH3-only	√		Activator
BAD	BH3-only	√		Sensitizer
BIK	BH3-only	√		Sensitizer
NOXA	BH3-only	√		Sensitizer
PUMA	BH3-only	√		Sensitizer