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. 2016 Jan 21;7(1):e2068. doi: 10.1038/cddis.2015.300

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Copyright © 2016 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Inhibition of gadd45ba or gadd45bb expression alleviates MTZ-induce edema and proteinuria. (a) Genomic organization of zebrafish gadd45ba and gadd45bb; target sites of the splice morpholinos and positions of primers used to determine the efficacy of MOs. (b) RT-PCR analysis of gadd45ba/bb mRNA in uninjected and gadd45ba/bb-splice-MO-injected embryos at 5 dpf. (c, d) qRT-PCR quantify of gadd45ba/bb mRNA level in wild-type fish and gadd45ba/bb-splice-MO-injected embryos at 3dpf and 5dpf. *P<0.05, **P<0.01. (e) Quantitation of the periorbital edema phenotype. (f) Quantitation of proteinuria with ELISA for GFP. *P<0.05, **P<0.01 versus NTR group