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. 2016 Jan 14;7(1):e2059. doi: 10.1038/cddis.2015.361

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Copyright © 2016 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Decreased RNA expression of autophagic markers in eutopic endometria from mice with endometriosis relative to controls. (a) The selected RNA samples from non-induced (control) and endometriosis-induced mice were analyzed using an RT²-PCR profiler array specific for 84 autophagy-related genes. A heat map shown depicting the measured C_T values across these specimens is presented. (b) A volcano plot is shown from the analyzed data presented in (a). The horizontal axis indicates significance (P=0.05) if targets are above the line; the dotted vertical bars denote at least a two-fold change in gene expression if targets are ⩾−1 or 1 Log₂ units. Red arrows indicate the autophagic markers that were decreased >2-fold with a P-value of <0.05. (c) Validation using TaqMan real-time PCR of specimens used in (a)

Decreased RNA expression of autophagic markers in eutopic endometria from mice with endometriosis relative to controls. (a) The selected RNA samples from non-induced (control) and endometriosis-induced mice were analyzed using an RT²-PCR profiler array specific for 84 autophagy-related genes. A heat map shown depicting the measured C_T values across these specimens is presented. (b) A volcano plot is shown from the analyzed data presented in (a). The horizontal axis indicates significance (P=0.05) if targets are above the line; the dotted vertical bars denote at least a two-fold change in gene expression if targets are ⩾−1 or 1 Log₂ units. Red arrows indicate the autophagic markers that were decreased >2-fold with a P-value of <0.05. (c) Validation using TaqMan real-time PCR of specimens used in (a)