Figure 2.

Core networks of contextualized control network. Network representation of the control network for cobalt chloride. Four genes (green) are contained in three common circuits (interactions highlighted in red), one negative autoregulation (RUNX1 —| RUNX1) and two positive feedback loops between RUNX1 and FOSL2, and ASCL1 and SOX2, respectively. No differentially regulated genes were found to be candidate genes for perturbation. The poor circuit coverage of the network is representative for the poor network response upon application of cobalt chloride. Most of the network perturbations can be recovered by the network