Table 4. Statistical comparison of simulated drugs in systemic lupus and rheumatoid arthritis.
| Case | Drug | AUC | Difference from AUC of uniform distribution |
|---|---|---|---|
| Systemic lupus (B cells) | Cyclosporine | 11.722 | 13.17% |
| Resveratrol | 8.918 | 33.94% | |
| Tetrachlorodibenzodioxin | 11.61 | 14.00% | |
| Systemic lupus (CD4 cells) | Acetaminophen | 18.721 | 12.93% |
| Estradiol | 16.627 | 22.66% | |
| Tetrachlorodibenzodioxin | 17.111 | 20.41% | |
| Valproic acid | 18.615 | 13.42% | |
| Rheumatoid arthritis (B cells) | Benzo(a)pyrene | 11.892 | 15.05% |
| Copper sulfate | 11.578 | 17.30% | |
| Cyclosporine | 12.169 | 13.08% | |
| Tetrachlorodibenzodioxin | 12.084 | 13.69% | |
| Valproic acid | 12.695 | 9.32% |
For systemic lupus in B and CD4 cells and rheumatoid arthritis in B cells, the area under the curve (AUC) of the cumulative enrichment distribution function is shown and compared against the AUC of a uniform distribution. Lower AUC values and higher difference from the uniform distribution indicate an enrichment of drug targets in multitarget combinations able to induce a higher change of the gene expression program. The most enriched drugs are highlighted in each case (bold) and agree with the experimentally induced drug.