Table 1. Clinical and molecular features of T-ALL patients and xenografts.

Sample ID	Gender	Age (years)	Phenotype	MRD risk	PGR/PPR	PDX genetic subgroup	PDX response to Givinostat
PD-TALL6	M	13	T Int	MR	PGR	TAL-LMO	Poor
PD-TALL8	F	3	T Int	MR	PPR	TLX1	Good
PD-TALL9	M	9	Early T	HR	Deceased	TAL-LMO	Poor
PD-TALL12	M	4	Early T	MR	PGR	TAL-LMO	Partial
PD-TALL15	M	7	T	HR	PPR	TAL-LMO	Good
PD-TALL16	M	5	T Mat	MR	PPR	TAL-LMO	Good
PD-TALL19	M	16	Early T	MR	Relapse	TLX3	Good
PD-TALL25	M	9	T	SR	PPR	TAL-LMO	Partial
PD-TALL43	M	15	T Int.	MR	PGR	TAL-LMO	Good

Abbreviations: F, female; HR, high risk; M, male; MR, medium risk; MRD, minimal residual disease; PDX, patient-derived xenograft; PGR, prednisone good responder; PPR, prednisone poor responder; SR, standard risk.