Table 2. Multivariate analysis for PFS and OS.

Variable	PFS, HR (95% CI)	P value	OS, HR (95% CI)	P value
Age (years, <60 versus ≥60)	1.11 (0.63–1.97)	0.70	1.21 (0.72–2.03)	0.48
Gender (male versus female)	1.13 (0.68–1.88)	0.64	1.25 (0.78–2.00)	0.35
Tumor location (colon versus rectum)	1.18 (0.70–1.99)	0.53	1.49 (0.93–2.41)	0.10
Tumor size (cm, <5 versus ≥5)	1.07 (0.56–2.05)	0.84	1.17 (0.66–2.08)	0.59
Tumor invasive depth (T1–2 versus T3–4)	0.84 (0.32–2.2)	0.72	0.88 (0.37–2.06)	0.76
TNM stage (I-II versus III-IV)	10.65 (5.2–21.7)	<0.001a	8.46 (4.69–15.2)	<0.001a
Lymph node status (<1 versus ≥1)	2.21 (1.17–4.19)	0.02a	2.55 (1.41–4.64)	0.002a
Distant metastasis (no versus yes)	7.4 (4.02–13.65)	<0.001a	6.53 (3.74–11.48)	<0.001a
CDC27 (low versus high)	1.78 (1.03–3.07)	0.04a	1.79 (1.09–2.94)	0.02a

Abbreviations: PFS, progression-free survival; OS, overall survival; HR, hazard ratio; CI, confidence interval.

^aStatistically significant.