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. 2016 Jan 28;7(1):e2073. doi: 10.1038/cddis.2015.412

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Copyright © 2016 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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XIAP overexpression inhibits ROS accumulation through upregulation of antioxidant capacity. (a) Fold induction of mitochondrial superoxides and (b) percentage of cells with high hydrogen peroxide-derived radicals in cells treated as indicated. Bars represent mean±S.E.M. relative to untreated cells. n=2–3, ^#P<0.001 (compared with SUM149). (c) Western immunoblot analysis of basal XIAP, SOD1 and SOD2 levels in SUM149 FG9, wtXIAP, +DW/AA and +H/A cells. Numbers represent densitometric analysis. (d) Normalized expression of the top most significantly differentially expressed genes shown as a heat map of over-(red) or under-(green) expressed genes in the oxidoreductase activity (GO:001649) GSEA category