Table 3. The top 20 ranked cell senescence genes.
| Gene symbol (ranked) | Global rank P-valuea | Global rank ratiob |
|---|---|---|
| CDKN2B | 2.40E−10 | 0.683162791 |
| CCND1 | 5.10E−10 | 0.759504452 |
| HDAC1 | 1.08E−09 | 0.658433129 |
| E2F1 | 1.09E−09 | 0.690059176 |
| E2F3 | 1.76E−09 | 0.710810668 |
| CCNE1 | 2.38E−09 | 0.72747951 |
| JUN | 2.68E−09 | 0.677420458 |
| PCNA | 3.56E−09 | 0.810169252 |
| SMAD3 | 3.97E−09 | 0.655630099 |
| MAPK1 | 1.06E−08 | 0.720590265 |
| SIRT6 | 1.09E−08 | 0.63268531 |
| TGFB2 | 1.13E−08 | 0.723337593 |
| SMAD1 | 1.37E−-08 | 0.651638075 |
| CDKN2C | 1.67E−08 | 0.653713064 |
| AKT1 | 1.68E−08 | 0.737075122 |
| CCNE2 | 1.73E−08 | 0.692954436 |
| TP63 | 1.87E−08 | 0.736742708 |
| PRKDC | 2.42E−08 | 0.717291837 |
| RBL1 | 3.11E−08 | 0.729568657 |
| MAPK3 | 3.34E−08 | 0.691720353 |
a
Represents the probability that a candidate gene would obtain these ranks by chance.
b
The overall ranking ratio from ToppGene.