Figure 5.

Pdcd4 deficiency attenuated the formation of atherosclerotic lesions in hyperlipidemia mice. apoe^−/− and pdcd4^−/−apoe^−/− (DKO) were fed with a high-fat diet from 8 to 16 weeks (apoe^−/−: n=7; DKO: n=5) or to 24 weeks to induce atherosclerotic lesions (apoe^−/−: n=5; DKO: n=7). H&E staining was performed to show atherosclerotic lesions (a) and oil red O staining was applied to show lipid in aortic root (b). Sections of aortic root were stained for macrophages (Moma-2) and T cells (CD3; original magnification × 200) in relation to total wall area (c). Face lesions on thoracic–abdominal aorta were stained with oil red O (d). *P<0.05; **P<0.01; ***P<0.001