Fig. 8.

Effect of REDD1 deletion on sepsis-induced changes in muscle and plasma cytokines. TNFα (A) and IL-6 (B) mRNA were determined, as were TNFα (C) and IL-6 (D) protein in gastrocnemius from WT and REDD1^−/− mice under sham control and septic conditions. Also, the impact of REDD1 deletion on sepsis-induced changes in plasma TNFα (E) and IL-6 (F) was determined. Gray bars represent WT mice (n = 10 sham and 15 septic), and black bars correspond to REDD1^−/− mice (n = 10 sham and 13 septic), with all values expressed relative to sham-WT, which was set to 100%. Horizontal bars indicate statistical differences between groups (P < 0.05). Values are expressed as means ± SE.