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. Author manuscript; available in PMC: 2016 Jul 8.
Published in final edited form as: Science. 2015 Nov 5;351(6269):aab2116. doi: 10.1126/science.aab2116

Figure 6. Analysis of My and Er progenitors in patients with aplastic anemia.

Figure 6

(A) To examine the consequences of HSC loss on progenitor subsets, BM cells from three AA patients and normal controls were subjected to the new sorting design shown in Fig. 1B. Representative flow plots from a single AA case and a control are shown. (B) Quantification of total CD34+ cells as a fraction of mononuclear cell (MNC) pool from controls (empty bars) versus AA (filled bars). (C-D) The CD34+ subset from controls and AA was further sub-divided into the stem (CD34+CD38−) and progenitor (CD34+CD38+) cell compartments. (E) Analysis of My enriched subsets (CMP F1, MEP F1 and GMP) in control and patients with AA. (F) Analysis of Er enriched subsets (CMP F2/F3, MEP F2/F3) in controls and AA. Bars indicate mean ± standard error from 3 controls and 3 cases of AA. Asterisks indicate significance based on t-test (** p<0.01, **** p<0.0001).