Table A7.
Covariate profiles based on deciles of 5-year risk
| Patient average covariate profiles based on deciles of 5-year risk of composite CVD first event | ||||||||||
| Risk decile | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
| 5-year risk (average) | 3.69% | 5.70% | 7.37% | 9.15% | 11.20% | 13.71% | 17.14% | 22.14% | 30.42% | 52.37% |
| Re-calculated 5-year risk | 3.46% | 5.43% | 6.95% | 8.53% | 10.36% | 12.57% | 15.64% | 20.07% | 27.23% | 44.18% |
| Socio-demographic characteristics | ||||||||||
| Sex (female) | 64% | 48% | 42% | 39% | 37% | 37% | 38% | 42% | 44% | 46% |
| Age (if male) | 49 | 55 | 59 | 62 | 65 | 67 | 71 | 74 | 77 | 81 |
| Age (if female) | 53 | 62 | 67 | 70 | 73 | 75 | 78 | 80 | 83 | 87 |
| Age (weighted average) | 52 | 59 | 62 | 65 | 68 | 70 | 73 | 76 | 80 | 84 |
| Most deprived quintile | 15% | 17% | 18% | 19% | 20% | 21% | 21% | 22% | 22% | 24% |
| SCAD diagnosis and severity | ||||||||||
| Other CHD | 11% | 17% | 20% | 22% | 24% | 24% | 25% | 26% | 25% | 20% |
| NSTEMI | 0% | 1% | 3% | 5% | 8% | 10% | 12% | 17% | 23% | 43% |
| STEMI | 1% | 4% | 8% | 12% | 13% | 14% | 13% | 9% | 6% | 4% |
| Unstable angina | 10% | 13% | 12% | 12% | 12% | 12% | 13% | 15% | 17% | 15% |
| Stable angina | 78% | 65% | 56% | 49% | 43% | 39% | 37% | 34% | 29% | 18% |
| PCI in last 6 months | 9% | 12% | 13% | 14% | 13% | 13% | 11% | 9% | 6% | 4% |
| CABG in last 6 months | 9% | 7% | 6% | 5% | 5% | 4% | 4% | 3% | 2% | 1% |
| Previous/recurrent MI | 2% | 6% | 10% | 14% | 18% | 23% | 26% | 29% | 32% | 43% |
| Use of nitrates | 10% | 16% | 19% | 21% | 24% | 28% | 33% | 37% | 43% | 56% |
| CVD risk factors | ||||||||||
| Current smoker | 31% | 35% | 36% | 37% | 38% | 38% | 37% | 35% | 32% | 30% |
| Ex-smoker | 27% | 30% | 31% | 32% | 32% | 33% | 34% | 34% | 34% | 34% |
| Never smoked | 41% | 35% | 33% | 31% | 30% | 29% | 29% | 31% | 33% | 36% |
| Hypertension | 69% | 70% | 71% | 71% | 72% | 74% | 76% | 79% | 83% | 87% |
| Diabetes | 4% | 8% | 10% | 12% | 14% | 16% | 18% | 21% | 24% | 32% |
| Total cholesterol (mmol/L) | 4.95 | 4.91 | 4.84 | 4.79 | 4.74 | 4.74 | 4.70 | 4.68 | 4.64 | 4.54 |
| HDL (mmol/L) | 1.41 | 1.37 | 1.35 | 1.35 | 1.35 | 1.35 | 1.36 | 1.37 | 1.37 | 1.35 |
| CVD co-morbidities | ||||||||||
| Heart failure | 5% | 7% | 9% | 12% | 15% | 19% | 27% | 37% | 52% | 73% |
| Peripheral arterial disease | 1% | 2% | 3% | 4% | 6% | 8% | 10% | 13% | 16% | 25% |
| Atrial fibrillation | 3% | 5% | 7% | 9% | 10% | 13% | 16% | 21% | 29% | 43% |
| Stroke | 0% | 1% | 1% | 2% | 3% | 5% | 8% | 14% | 22% | 39% |
| Non-CVD co-morbidities | ||||||||||
| Chronic kidney disease | 2% | 2% | 3% | 4% | 4% | 5% | 7% | 9% | 12% | 20% |
| Chronic obstructive pulmonary disease | 20% | 20% | 20% | 21% | 22% | 23% | 25% | 27% | 28% | 30% |
| Cancer | 4% | 5% | 6% | 7% | 8% | 9% | 11% | 13% | 14% | 12% |
| Chronic liver disease | 0% | 1% | 1% | 1% | 1% | 1% | 1% | 1% | 1% | 1% |
| Psychosocial characteristics | ||||||||||
| Depression at diagnosis | 20% | 17% | 15% | 15% | 14% | 14% | 15% | 17% | 18% | 21% |
| Anxiety at diagnosis | 7% | 6% | 6% | 7% | 7% | 7% | 8% | 8% | 10% | 12% |
| Biomarkers | ||||||||||
| Heart rate (b.p.m.) | 72 | 71 | 71 | 71 | 71 | 71 | 72 | 73 | 74 | 76 |
| Creatinine (mmol/L) | 88 | 92 | 95 | 96 | 98 | 100 | 101 | 104 | 109 | 125 |
| White cell count (109/L) | 6.81 | 7.05 | 7.19 | 7.31 | 7.44 | 7.54 | 7.62 | 7.76 | 7.88 | 8.22 |
| Haemoglobin (g/100 mL) | 14.26 | 14.26 | 14.16 | 14.05 | 13.88 | 13.70 | 13.48 | 13.16 | 12.81 | 12.20 |