Table 1.
Affinity and selectivity of FECIMBI-36
| Targets | Ki (nM) | Targets | Ki (nM) |
|---|---|---|---|
| 5-HT1A | 1433 | D1 | >10,000 |
| 5-HT1B | >10,000 | D2 | 1394 |
| 5-HT1D | >10,000 | D3 | 1076 |
| 5-HT1E | >10,000 | KAR | >10,000 |
| 5-HT2A | 1.0 | D4 | >1000 |
| 5-HT2B | 2.8 | D5 | >10,000 |
| 5-HT2C | 1.7 | DAT | >10,000 |
| 5-HT3 | >10,000 | DOR | >10,000 |
| 5-HT7 | >10,000 | EP | >10,000 |
| Adenosine | >10,000 | GABA | >10,000 |
| α1A–1C | >10,000 | H4 | 2126 |
| α2A | 551 | HERG | >10,000 |
| α2B | 1256 | KOR | 558 |
| α2C | 656 | M | >10,000 |
| β1 | >10,000 | H3, H4 | >10,000 |
| β2 | 3220 | MDR1 | >10,000 |
| β3 | >10,000 | H2 | 1983 |
| BZP | >10,000 | H1 | 150 |
| Ca++ | >10,000 | MOR | 149 |
| AMPA | >10,000 | mGluR | >10,000 |
| NET | 208 | NMDA | >10,000 |
| NK | >10,000 | SERT | 284 |
| Sigma1 | 499 | Sigma2 | 51 |
| Na+ | >10,000 | NT1 | >10,000 |
| CB1, CB2 | >10,000 | I | >10,000 |
| mGluRs | >10,000 | VMAT | >10,000 |
| NOP | >10,000 | NMDA | >10,000 |
| PBR | 876 | NT | >10,000 |
| Oxytocin | >10,000 | PKC | >10,000 |
| Smoothened | >10,000 | V1–2 | >10,000 |
| Agonist assays | 5-HT2AR | 5-HT2BR | 5-HT2CR |
| Emax: 63.4% | Emax: 18.4% | Emax: 100% |