Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
| Parameter | Value |
|---|---|
| Molecular weight (g/mol) | 516 |
| pKa | 4.56 |
| LogP | 3.74 |
| Caco-2 permeability (10−6 cm/s) | 7.06 |
| Aqueous solubility at pH 7 (mg/mL) | 30 |
| Rbp in rat, dog, human | 1.38, 1.14, 1.06 |
| %fu in rat, dog, human plasma | 15.8, 14.0, 10.0 |
| CLp in rat and dog (mL·min−1·kg−1) | 69.7, 26.3 |
| Human CLp predicted (from IVIVE, SSSrat, SSSdog, FCIM, and TSrat-dog, mL·min−1·kg−1) | 12.3, 10.3, 11.1, 6.42, 9.53 |
