Table 6. Summary of metabolomic and modified cytology techniques for cyst-fluid analysis.
| Year | First author | Biomarker | Sample size | Sample distribution | Phase | Observations |
|---|---|---|---|---|---|---|
| 2008 | Pitman et al.73 | AECs | 18 | 6 Malignant 12 Non-malignant | 2 | 5/6 (83%) malignant cysts+AEC vs. 4/12 (33%) non-malignant cysts+AEC |
| 2010 | Pitman et al.74 | AECs | 112 | 39 Malignant 73 Pre-malignant | 2 | Malignancy: AEC sensitivity 72%, specificity 85% |
| 2013 | Park et al.71 | Metabolomics: glucose and kynurenine | 45 | 31 Mucinous 14 Non-mucinous | 1 | Mucinous cysts: glucose ROC 0.92 and kynurenine ROC 0.94) |
AEC, atypical epithilial cell; ROC, region of interest.