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Mean nighttime pH ≥4 holding time ratio (left) and pH ≥5 holding time ratio (right) in the Japanese (12–24 h post dose) and UK (20:00–08:00 h) phase I, randomized, double-blind, placebo-controlled, single rising-dose studies in healthy male subjects receiving a single TAK-438 dose (1–120 mg in Japan and 1–40 mg in the UK; Pharmacodynamic analysis set; Japan N=82, UK N=63).
