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. 2015 Jul 16;6(7):e101. doi: 10.1038/ctg.2015.28

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Copyright © 2015 American College of Gastroenterology

Clinical and Translational Gastroenterology is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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In vivo imaging of colon in CPC;Apc mouse. (a) White-light image of colon in CPC;Apc mouse shows the presence of polyp (arrow). Pathology was evaluated along (dashed) red lines. (b) NIR fluorescence image after topical administration of QRH*-Cy5.5 shows increased intensity from polyp (arrow) and several flat lesions (arrowheads) with heterogeneous pattern. (c) Image with PEH*-Cy5.5 shows minimal signal. (d) White-light image shows no grossly visible lesions (polyps). (e) NIR fluorescence image with QRH*-Cy5.5 shows the presence of flat lesions (arrowheads). (f) Image with PEH*-Cy5.5 shows minimal signal. NIR, near-infrared.