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. 2013 Apr 4;346:f1378. doi: 10.1136/bmj.f1378

Table 3.

GRADE summary of findings table showing quality of evidence for effect of higher potassium intake on selected health outcomes in children

Outcomes Effect
(95% CI)
No of participants
(studies)
Quality of evidence
(GRADE)
Comments
Resting systolic blood pressure* (assessed directly in children; follow-up 0.75-1 month; units mm Hg; better indicated by lower values) MD 0.28 lower (1.05 lower to 0.49 higher) 236 (3) Low 1 of 3 studies was not randomised; downgraded owing to high risk of bias and imprecision.
Resting systolic blood pressure† (assessed in adults; follow-up 1-36 months; units mm Hg; better indicated by lower values) MD 3.49 lower (5.15 to 1.82 lower) 1892 (21) Moderate Downgraded owing to indirectness
Total cholesterol (assessed directly in children) No studies in children reported on this outcome
Total cholesterol† (assessed in adults; follow-up 1-2 months; units mmol/L; better indicated by lower values) MD 0.12 lower (0.33 lower to 0.09 higher) 208 (3) Moderate Downgraded owing to indirectness
Plasma noradrenaline (assessed directly in children) No studies in children reported on this outcome
Plasma noradrenaline† (assessed in adults; follow-up 1-2.5 months; units pg/mL; better indicated by lower values) MD 4.32 lower (23.78 lower to 15.13 higher) 152 (3) Moderate Downgraded owing to indirectness
Minor side effects (assessed directly in children) No studies in children reported on this outcome
Minor side effects (assessed in adults) No studies in adults reported on this outcome

MD=mean difference.

*One observational cohort study in children is consistent with beneficial effect of increased potassium on blood pressure over time.

†Data from adults used as proxy for children.